If you’re looking for a supplement to help with energy, mood, and memory, you may want to consider pregnenolone. Pregnenolone is a hormone that’s produced in the body, and it’s sometimes called the “mother hormone” because it’s the precursor to other hormones, including progesterone, estrogen, and testosterone.

Pregnenolone levels decline with age, so some people take it as a supplement to try to improve energy, mood, and memory. It’s also sometimes used to help with conditions such as adrenal insufficiency, Alzheimer’s disease, and depression.

Pregnenolone is available in supplements that you can take by mouth. It’s also available in creams that you can apply to your skin.

The following are four of the best pregnenolone supplements, based on customer reviews.

1. Life Extension Neuro-Mag Magnesium L-Threonate with Pregnenolone Capsules

This supplement from Life Extension contains magnesium L-threonate and pregnenolone. Magnesium L-threonate is a form of magnesium that’s able to cross the blood-brain barrier, which means it may be able to improve brain function.

Pregnenolone is a hormone that’s produced in the body, and it’s sometimes called the “mother hormone” because it’s the precursor to other hormones, including progesterone, estrogen, and testosterone.

Pregnenolone levels decline with age, so some people take it as a supplement to try to improve energy, mood, and memory. It’s also sometimes used to help with conditions such as adrenal insufficiency, Alzheimer’s disease, and depression.

The capsules are vegetarian and gluten-free.

2. Jarrow Formulas Pregnenolone Cream

This cream from Jarrow Formulas contains pregnenolone, as well as other ingredients such as aloe vera and coconut oil.

Pregnenolone is a hormone that’s produced in the body, and it’s sometimes called the “mother hormone” because it’s the precursor to other hormones, including progesterone, estrogen, and testosterone.

Pregnenolone levels decline with age, so some people take it as a supplement to try to improve energy, mood, and memory. It’s also sometimes used to help with conditions such as adrenal insufficiency, Alzheimer’s disease, and depression.

The cream is non-GMO and cruelty-free.

3. NOW Supplements, Pregnenolone 50 mg with Vitamin B-6 & Folic Acid

This supplement from NOW Supplements contains pregnenolone, as well as vitamin B-6 and folic acid.

Pregnenolone is a hormone that’s produced in the body, and it’s sometimes called the “mother hormone” because it’s the precursor to other hormones, including progesterone, estrogen, and testosterone.

Pregnenolone levels decline with age, so some people take it as a supplement to try to improve energy, mood, and memory. It’s also sometimes used to help with conditions such as adrenal insufficiency, Alzheimer’s disease, and depression.

Vitamin B-6 is important for brain function, and folic acid is important for pregnant women to take to help prevent birth defects.

The capsules are vegan and Kosher.

4. Smoky Mountain Naturals Pregnenolone Cream

This cream from Smoky Mountain Naturals contains pregnenolone, as well as other ingredients such as aloe vera, shea butter, and jojoba oil.

Pregnenolone is a hormone that’s produced in the body, and it’s sometimes called the “mother hormone” because it’s the precursor to other hormones, including progesterone, estrogen, and testosterone.

Pregnenolone levels decline with age, so some people take it as a supplement to try to improve energy, mood, and memory. It’s also sometimes used to help with conditions such as adrenal insufficiency, Alzheimer’s disease, and depression.

The cream is non-GMO and cruelty-free.

Now that we’ve looked at four of the best pregnenolone supplements, let’s compare them in terms of key features.

Price

Life Extension Neuro-Mag Magnesium L-Threonate with Pregnenolone Capsules: $19.97 for 60 capsules

Jarrow Formulas Pregnenolone Cream: $11.99 for 2 ounces

NOW Supplements, Pregnenolone 50 mg with Vitamin B-6 & Folic Acid: $11.99 for 60 capsules

Smoky Mountain Naturals Pregnenolone Cream: $24.95 for 4 ounces

Form

Life Extension Neuro-Mag Magnesium L-Threonate with Pregnenolone Capsules: Capsules

Jarrow Formulas Pregnenolone Cream: Cream

NOW Supplements, Pregnenolone 50 mg with Vitamin B-6 & Folic Acid: Capsules

Smoky Mountain Naturals Pregnenolone Cream: Cream

Other Ingredients

Life Extension Neuro-Mag Magnesium L-Threonate with Pregnenolone Capsules: Magnesium L-threonate

Jarrow Formulas Pregnenolone Cream: Aloe vera, coconut oil

NOW Supplements, Pregnenolone 50 mg with Vitamin B-6 & Folic Acid: Vitamin B-6, folic acid

Smoky Mountain Naturals Pregnenolone Cream: Aloe vera, shea butter, jojoba oil

Vegetarian/Vegan

Life Extension Neuro-Mag Magnesium L-Threonate with Pregnenolone Capsules: Vegetarian

Jarrow Formulas Pregnenolone Cream: No

NOW Supplements, Pregnenolone 50 mg with Vitamin B-6 & Folic Acid: Vegan

Smoky Mountain Naturals Pregnenolone Cream: No

Gluten-Free

Life Extension Neuro-Mag Magnesium L-Threonate with Pregnenolone Capsules: Gluten-Free

Jarrow Formulas Pregnenolone Cream: No

NOW Supplements, Pregnenolone 50 mg with Vitamin B-6 & Folic Acid: No

Smoky Mountain Naturals Pregnenolone Cream: No

Non-GMO

Life Extension Neuro-Mag Magnesium L-Threonate with Pregnenolone Capsules: No

Jarrow Formulas Pregnenolone Cream: Yes

NOW Supplements, Pregnenolone 50 mg with Vitamin B-6 & Folic Acid: No

Smoky Mountain Naturals Pregnenolone Cream: Yes

Cruelty-Free

Life Extension Neuro-Mag Magnesium L-Threonate with Pregnenolone Capsules: No

Jarrow Formulas Pregnenolone Cream: Yes

NOW Supplements, Pregnenolone 50 mg with Vitamin B-6 & Folic Acid: No

Smoky Mountain Naturals Pregnenolone Cream: Yes

Kosher

Life Extension Neuro-Mag Magnesium L-Threonate with Pregnenolone Capsules: No

Jarrow Formulas Pregnenolone Cream: No

NOW Supplements, Pregnenolone 50 mg with Vitamin B-6 & Folic Acid: Yes

Smoky Mountain Naturals Pregnenolone Cream: No

Based on the above comparison, the best pregnenolone supplement is Life Extension Neuro-Mag Magnesium L-Threonate with Pregnenolone Capsules. This supplement contains magnesium L-threonate, which is a form of magnesium that’s able to cross the blood-brain barrier, and it also contains pregnenolone, which is a hormone that’s produced in the body and is the precursor to other hormones. The capsules are vegetarian and gluten-free.