If you’re looking for a natural way to improve your mood, then you may want to consider taking SAM-e. SAM-e is a dietary supplement that’s been shown to provide a number of benefits, including reducing inflammation, improving joint function, and boosting cognitive performance.

But with so many different SAM-e supplements on the market, it can be hard to know which one to choose.

To help you make an informed decision, we’ve put together a list of the five best SAM-e supplements, based on factors like price, key differentiators, and user reviews.

1. Life Extension SAM-e Complete 400mg

This supplement from Life Extension is a good option for those who are looking for a high-quality product at a reasonable price. Each tablet contains 400mg of SAM-e, and the recommended dosage is one tablet per day.

One of the key differentiators of this product is that it’s enteric coated, which means that it’s designed to dissolve in the small intestine rather than the stomach. This is important because SAM-e is a delicate molecule that can be easily broken down by stomach acid.

Another key feature is that this product is vegetarian-friendly. The capsules are made from cellulose, which is a type of plant-based fiber.

User reviews are generally positive, with many people reporting that this supplement has helped them with depression, anxiety, and other mood disorders.

2. Jarrow Formulas SAM-e 200mg

This supplement from Jarrow Formulas is a good option for those who are looking for a lower-dose product. Each tablet contains 200mg of SAM-e, and the recommended dosage is one to three tablets per day.

One of the key differentiators of this product is that it’s enteric coated, which means that it’s designed to dissolve in the small intestine rather than the stomach. This is important because SAM-e is a delicate molecule that can be easily broken down by stomach acid.

Another key feature is that this product is vegan-friendly. The capsules are made from cellulose, which is a type of plant-based fiber.

User reviews are generally positive, with many people reporting that this supplement has helped them with depression, anxiety, and other mood disorders.

3. Natrol SAM-e Mood & Joint Support

This supplement from Natrol is a good option for those who are looking for a product that supports both mood and joint health. Each tablet contains 400mg of SAM-e, and the recommended dosage is one tablet per day.

One of the key differentiators of this product is that it’s enteric coated, which means that it’s designed to dissolve in the small intestine rather than the stomach. This is important because SAM-e is a delicate molecule that can be easily broken down by stomach acid.

Another key feature is that this product is free from artificial colors, flavors, and preservatives.

User reviews are generally positive, with many people reporting that this supplement has helped them with depression, anxiety, and other mood disorders.

4. Now Foods SAM-e 200mg

This supplement from Now Foods is a good option for those who are looking for a lower-dose product. Each tablet contains 200mg of SAM-e, and the recommended dosage is one to three tablets per day.

One of the key differentiators of this product is that it’s enteric coated, which means that it’s designed to dissolve in the small intestine rather than the stomach. This is important because SAM-e is a delicate molecule that can be easily broken down by stomach acid.

Another key feature is that this product is vegetarian-friendly. The capsules are made from cellulose, which is a type of plant-based fiber.

User reviews are generally positive, with many people reporting that this supplement has helped them with depression, anxiety, and other mood disorders.

5. Doctor’s Best SAM-e 400mg

This supplement from Doctor’s Best is a good option for those who are looking for a high-quality product. Each tablet contains 400mg of SAM-e, and the recommended dosage is one tablet per day.

One of the key differentiators of this product is that it’s enteric coated, which means that it’s designed to dissolve in the small intestine rather than the stomach. This is important because SAM-e is a delicate molecule that can be easily broken down by stomach acid.

Another key feature is that this product is GMO-free.

User reviews are generally positive, with many people reporting that this supplement has helped them with depression, anxiety, and other mood disorders.